Current View of the Buffalo Industry

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Modelling the Product Development performance of Colombian Companies

Organised by: Cranfield UniversityThis paper presents the general model of the Product Development Process (PDP) in the Metal mechanics Industry in Barranquilla-Colombia, since this sector contributes significantly to the productivity of this industrial city. This case study counted on a five-company sample. The main goal was to model the current conditions of the PDP according to the Concurrent Engineering philosophy. The companies were selected according to their productive profile, in order to contrast differences regarding the structure of their productive processes, conformation of multidisciplinary teams, integration of different areas, customers and suppliers to the PDP; human resources, information, technology and marketing constraints.Mori Seiki – The Machine Tool Compan

Neonatal Diabetes Mellitus.

Neonatal Diabetes (ND) mellitus is a rare genetic disease (1 in 90,000 live births). It is defined by the presence of severe hyperglycaemia associated with insufficient or no circulating insulin, occurring mainly before 6 months of age and rarely between 6 months and 1 year. Such hyperglycaemia requires either transient treatment with insulin in about half of cases, or permanent insulin treatment. The disease is explained by two major groups of mechanism: malformation of the pancreas with altered insulin-secreting cells development/survival or abnormal function of the existing pancreatic β cell. The most frequent genetic causes of neonatal diabetes mellitus with abnormal β cell function are abnormalities of the 6q24 locus and mutations of the ABCC8 or KCNJ11 genes coding for the potassium channel in the pancreatic β cell. Other genes are associated with pancreas malformation or insufficient β cells development or destruction of β cells. Clinically, compared to patients with an ABCC8 or KCNJ11 mutation, patients with a 6q24 abnormality have lower birth weight and height, are younger at diagnosis and remission, and have a higher malformation frequency. Patients with an ABCC8 or KCNJ11 mutation have neurological and neuropsychological disorders in all those tested carefully. Up to 86% of patients who go into remission have recurrent diabetes when they reach puberty, with no difference due to the genetic origin. All these results reinforce the importance of prolonged follow-up by a multidisciplinary pediatric team, and later doctors specializing in adult medicine. 90% of the patients with an ABCC8 or KCNJ11 mutation as well as those with 6q24 anomalies are amenable to a successful switch from insulin injection to oral sulfonylureas

A review of expansive phenomena in Wagenburg North Tunnel

The paper deals on tunnelling and swelling in anhydritic-gypsiferous claystones. The geology of the Gipskeuper in Baden-Württemberg (Germany) and the phenomenology of expansions in Wagenburg North tunnel are described. Consistent swelling triggering events, mechanisms and exhaustion causes were identified using a thermo-hydro-chemo-mechanical theoretical analysis. It is suggested that long-term swelling in tunnels excavated through anhydritic-gypsiferous claystones is a result of solvent-way gypsum crystal growth due to ventilation induced groundwater evaporation and rock drying; an opposite concept to the usual consequences of drying in argillaceous materials, which causes shrinkage strains

Synthetic soil crusts against green-desert transitions : a spatial model

Altres ajuts: Botin Foundation (Banco Santander through its Santander Universities Global Division) i CERCA Programme/Generalitat de CatalunyaSemiarid ecosystems are threatened by global warming due to longer dehydration times and increasing soil degradation. Mounting evidence indicates that, given the current trends, drylands are likely to expand and possibly experience catastrophic shifts from vegetated to desert states. Here, we explore a recent suggestion based on the concept of ecosystem terraformation, where a synthetic organism is used to counterbalance some of the nonlinear effects causing the presence of such tipping points. Using an explicit spatial model incorporating facilitation and considering a simplification of states found in semiarid ecosystems including vegetation, fertile and desert soil, we investigate how engineered microorganisms can shape the fate of these ecosystems. Specifically, two different, but complementary, terraformation strategies are proposed: Cooperation -based: C -terraformation; and Dispersion -based: D -terraformation. The first strategy involves the use of soil synthetic microorganisms to introduce cooperative loops (facilitation) with the vegetation. The second one involves the introduction of engineered microorganisms improving their dispersal capacity, thus facilitating the transition from desert to fertile soil. We show that small modifications enhancing cooperative loops can effectively modify the aridity level of the critical transition found at increasing soil degradation rates, also identifying a stronger protection against soil degradation by using the D -terraformation strategy. The same results are found in a mean-field model providing insights into the transitions and dynamics tied to these terraformation strategies. The potential consequences and extensions of these models are discussed

Early-life DNA methylation profiles are indicative of age-related transcriptome changes.

BACKGROUND: Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prevented by anti-aging interventions, but the relationship of altered methylation to gene expression is poorly understood. RESULTS: Paired analysis of the hippocampal methylome and transcriptome with aging of male and female mice demonstrates that age-related differences in methylation and gene expression are anti-correlated within gene bodies and enhancers. Altered promoter methylation with aging was found to be generally un-related to altered gene expression. A more striking relationship was found between methylation levels at young age and differential gene expression with aging. Highly methylated gene bodies and promoters in early life were associated with age-related increases in gene expression even in the absence of significant methylation changes with aging. As well, low levels of methylation in early life were correlated to decreased expression with aging. This relationship was also observed in genes altered in two mouse Alzheimer\u27s models. CONCLUSION: DNA methylation patterns established in youth, in combination with other epigenetic marks, were able to accurately predict changes in transcript trajectories with aging. These findings are consistent with the developmental origins of disease hypothesis and indicate that epigenetic variability in early life may explain differences in aging trajectories and age-related disease

Measurement of the Fermi Constant by FAST

An initial measurement of the lifetime of the positive muon to a precision of 16 parts per million (ppm) has been performed with the FAST detector at the Paul Scherrer Institute. The result is tau_mu = 2.197083 (32) (15) microsec, where the first error is statistical and the second is systematic. The muon lifetime determines the Fermi constant, G_F = 1.166353 (9) x 10^-5 GeV^-2 (8 ppm).Comment: 15 pages, 6 figure